Posted by: Thixia | October 22, 2008

MS and Anxiety Disorders

Anxiety disorders and their clinical correlates in multiple sclerosis patients.

Department of Psychiatry,

Sunnybrook Health SciencesCentre,

2075 Bayview Avenue,

Toronto, Ontario,


M4N 3M5.




To assess prevalence rates and clinical correlates of anxiety disorders in patients with multiple sclerosis (MS).




Demographic and neurological data were collected on 140 consecutive clinic attendees, and their lifetime and point prevalence’s of anxiety disorders were determined with the Structured Clinical Interview for DSM-IV disorders (SCID-IV). All subjects completed the self-report Hospital Anxiety and Depression Scale (HADS). Suicidal intent was rated with the Beck Suicide Scale (BSS), psychosocial stressors and supports were quantified with Social Stress and Support Interview (SSSI), and cognition assessed with Neuropsychological Screening Battery for MS.




The lifetime prevalence of any

  • anxiety disorder                                35.7%,
  • with panic disorder                          10.0%,
  • obsessive compulsive disorder         8.6%, and
  • generalized anxiety disorder          18.6%,


the most common diagnoses obtained.


Subjects with an anxiety disorder were more likely to be female, have a history of depression, drink to excess, report higher social stress, and have contemplated suicide. The diagnosis of an anxiety disorder had been missed in the majority of subjects, therefore, they had not received treatment. A discriminate function analysis identified a series of variables that correctly classified 75% of patients with an anxiety disorder.




Anxiety disorders are common in patients with MS, but are frequently overlooked and under-treated. Risk factors include being female, a co-morbid diagnosis of depression, and limited social support. Clinicians should evaluate all MS subjects for anxiety disorders, as they represent a treatable cause of disability in MS.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )


Connecting to %s


%d bloggers like this: