Posted by: Thixia | March 11, 2008

Study- oral high-dose methylprednisolone

Evaluation of response of multiple sclerosis (MS) relapse to oral high-dose methylprednisolone: usefulness of MS functional composite and Expanded Disability Status Scale

To compare the usefulness of multiple sclerosis functional composite (MSFC) to the Expanded Disability Status Scale (EDSS) in assessing functional changes related to relapse.

A prospective 12-week follow-up study after relapse was conducted among 14 multiple sclerosis (MS) patients treated with oral high-dose (1 g) methylprednisolone for 3 days.

MSFC and the EDSS were assessed on day 0, before treatment and, 1, 4 and 12 weeks afterwards. In relapses, EDSS (2.5 ± 1.2 to 3.8 ± 1.0) and z-score of the MSFC (0.15 ± 0.58 to −0.59 ± 0.70) worsened.

After 1 week of treatment, the EDSS improved (3.3 ± 1.2; P = 0.002) while the MSFC did not change significantly. At week 4, EDSS improvement was maximal (2.8 ± 1.3; P = 0.001). At week 12, EDSS remained stable whereas z-score continued improving (0.26 ± 0.74). z-9peg-hole-test was the most sensitive subtest.

There was correlation between baseline values of both scales (−0.620, P < 0.05) and between changes due to relapse (−0.535, P < 0.05). 78.5% of patients had improved at week 4 (35.7% at week 1). There were no serious adverse effects. MSFC and the EDSS were sensitive to changes due to relapses, although the dynamics for restoring baseline function were different.

Our data support the usefulness of both scales in clinical trials, providing complementary information about outcome of MS patients with relapses.

• M. PascualaaDepartment of Neurology, Hospital Universitario La Fe, Valencia,
• BoscáaaDepartment of Neurology, Hospital Universitario La Fe, Valencia,
• F. CoretbbDepartment of Neurology, Hospital Clínico Universitario, Valencia, Spain,
• M. EscutiaaaDepartment of Neurology, Hospital Universitario La Fe, Valencia,
• BernatbbDepartment of Neurology, Hospital Clínico Universitario, Valencia, Spain and
• CasanovaaaDepartment of Neurology, Hospital Universitario La Fe, Valencia
o aDepartment of Neurology, Hospital Universitario La Fe,Valencia;and
o bDepartment of Neurology, Hospital Clínico Universitario, Valencia, Spain

Advertisements

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s

Categories

%d bloggers like this: