Posted by: Thixia | March 4, 2008

Tetanus vaccination and risk of multiple sclerosis

Tetanus vaccination and risk of multiple sclerosis: a systematic review.


To conduct a systematic review on the association between tetanus vaccination and the risk of multiple sclerosis (MS).


The authors searched the databases Medline, LILACS, EMBASE, and Science Citation Index including the period 1966 to September 1, 2005. Eligible studies had to meet the following inclusion criteria: presentation of original data, case-control or cohort design, physician-confirmed diagnosis of MS as the outcome of interest, attempt to ascertain vaccinations in a period before the diagnosis, and report of an association measure between tetanus vaccination and incidence of MS, and its 95% CI or enough information to compute it. Study specific log ORs were weighted by the inverse of their variances to obtain a pooled estimate and its 95% CI.


The OR of MS associated with history of tetanus vaccination was 0.67 (95% CI: 0.55 to 0.81). There was little indication of heterogeneity of results across studies.

CONCLUSION: Tetanus vaccination is associated with a lower risk of multiple sclerosis.

Department of Epidemiology,

Harvard School of Public Health, Boston, MA 02115, USA.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out / Change )

Twitter picture

You are commenting using your Twitter account. Log Out / Change )

Facebook photo

You are commenting using your Facebook account. Log Out / Change )

Google+ photo

You are commenting using your Google+ account. Log Out / Change )

Connecting to %s


%d bloggers like this: